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The skeletal and cardiac muscle mass troponin T and troponin I are immunologically distinct entities. [three] Independent sets of genes code for these proteins.
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The solution lies in the fact there are a number of isoforms of each troponin subunit which can be encoded by unique genes, a number of which happen to be expressed selectively in cardiac muscle. Although TnI and TnT have unique cardiac and skeletal isoforms, they share a common isoform of TnC: the gradual-twitch skeletal muscle mass isoform (ssTnC) (
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g. triphenyltetrazolium chloride, lactate elution). A completely new experimental examine substantiates this idea, whereby hs-cTn assays were being capable to detect serum elevations of troponin from necrosis of a few milligrams of myocardium: an quantity of irreversible damage beyond the resolution of any imaging procedure.88
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